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Figure 9 | Journal of Neuroinflammation

Figure 9

From: Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation

Figure 9

Akt/HSP90 complex formation detected by immunoprecipitation analysis in response to stimulation with 20 ng/ml VEGF of BAECs cultured in the presence of Aβ25–35 (A) for 24 h and in combination with 2 mM NAC (B). Densitometric analysis of the blots analyzed for statistical significance are reported in the bar graphs (C) (*P < 0.05 versus 0 min of each separate treatment group and #P < 0.02 versus 0 min of untreated control cells (white bars), n =4). VEGF, vascular endothelial growth factor; eNOS, endothelial nitric oxide synthase; min, minutes; NAC, N-acetyl-cysteine; HSP90, heat shock protein 90.

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