Figure 5

MH-mediated inhibition of PGE₂ and PGE₂-GE formation in RAW264.7 cells without external addition of 2-AG. Concentration-dependent inhibition of (A) PGE₂ and (B) PGE₂-GE formation (picogram per million of cell) in RAW264.7 intact cells previously stimulated with LPS (1 mg mL⁻¹) ATP (1 mM) and thapsigargin (2 μM) for 8 h. (C) PGE₂ and PGE₂-GE formation inhibition upon different concentrations of MH (expressed as % of vehicle-treated cells). ^* P < 0.05, ^** P < 0.01 MH treated samples vs. vehicle for panels (A) and (B); ^* P < 0.05, ^** P < 0.01 PGE₂-GE vs. PGE₂ for panel (C).