Figure 5From: 4′-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenationMH-mediated inhibition of PGE2 and PGE2-GE formation in RAW264.7 cells without external addition of 2-AG. Concentration-dependent inhibition of (A) PGE2 and (B) PGE2-GE formation (picogram per million of cell) in RAW264.7 intact cells previously stimulated with LPS (1 mg mL−1) ATP (1 mM) and thapsigargin (2 μM) for 8 h. (C) PGE2 and PGE2-GE formation inhibition upon different concentrations of MH (expressed as % of vehicle-treated cells). * P < 0.05, ** P < 0.01 MH treated samples vs. vehicle for panels (A) and (B); * P < 0.05, ** P < 0.01 PGE2-GE vs. PGE2 for panel (C).Back to article page