Pneumococcal meningitis induces C/EBPδ expression. c/ebpδ mRNA (A) and protein expression in wild-type brain tissue (B,
D) at different time points after intracisternal inoculation with S. pneumoniae. Arrows indicate epithelial cells expressing C/EBPδ in vessels of the brain parenchyma (BP) and meningeal cells. Arrowheads indicate glial cells in brain parenchyma expressing C/EBPδ (BP). Asterisk indicate C/EBPδ positive cells in the choroid plexus (CP). Original magnification ×10, inset ×20. Data are expressed as median with interquartile ranges and 5% to 95% percentiles (n = 6 for controls; n = 12 at both t = 6 and t = 30 h post infection). **P < 0.01.