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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Who let the dogs out?: detrimental role of Galectin-3 in hypoperfusion-induced retinal degeneration

Figure 3

Immunohistochemical labeling of photoreceptor cells. (A) Recoverin-labeled WT control retinas reveal labeling of outer segment at the outer border of the retina, as well as weaker labeling of inner segments and photoreceptor cell bodies. (B) Rhodopsin labeling of WT control animals shows inner and outer segments as well as photoreceptor cell bodies in the ONL. (C) WT hypo retinas display recoverin labeling of disorganized inner and outer segments as well as labeling of photoreceptor cell bodies. (D) WT hypo specimens display strong rhodopsin labeling of outer segments and labeling of inner segments and photoreceptor cell bodies. The specimens show a disorganized appearance as well as displaced rhodopsin expression to cell bodies in the outer nuclear layer (arrows). (E) KO control retinas reveal recoverin labeling of inner and outer segments as well as photoreceptor cell bodies. (F) Rhodopsin labeling of KO control animals shows strong labeling of inner and outer segments and weaker labeling of photoreceptor cell bodies. (G) Recoverin-labeled KO hypoperfused retinas display labeling of inner and outer segments as well as photoreceptor cell bodies. (H) KO hypo mice reveal very strong labeling of the outer segments and weaker labeling of inner segments. Some displacement of rhodopsin expression to cell bodies in the ONL is observed. Scale bar = 50 μm.

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