Table 1 Epitope prediction by BIMAS algorithm: estimated binding affinities of Aβ-derived nonamers to various HLA molecules

A1

20

VFFAEDVGS

18

A02.01

16

KLVFFAEDV

453

33

GLMVGGVVI

15

A02.05

31

IIGLMVGGV

6

A24

9

GYEVHHQKL

396

A3

16

KLVFFAEDV

2

A11.01

-

-

-

A31.01

-

-

-

A33.02

7

DSGYEVHHQ

1.5

A68.01

24

VGSNKGAII

24

B14

4

FRHDSGYEV

4

B27.02

4

FRHDSGYEV

20

2

AEFRHDSGY

15

B27.05

4

FRHDSGYEV

600

2

AEFRHDSGY

75

15

QKLVFFAED

27

8

SGYEVHHQK

25

B28.01

-

-

-

B35.01

26

SNKGAIIGL

3

B37.01

-

-

-

B38.01

12

VHHQKLVFF

30

B39.01

-

-

-

B39.02

27

NKGAIIGLM

12

B40

2

AEFRHDSGY

32

10

YEVHHQKLV

16

B44.03

2

AEFRHDSGY

240

B51.01

24

VGSNKGAII

104

32

IGLMVGGVV

57

28

KGAIIGLMV

24

B51.02

33

GLMVGGVVI

132

24

VGSNKGAII

88

28

KGAIIGLMV

28

B51.03

32

IGLMVGGVV

52

24

VGSNKGAII

48

28

KGAIIGLMV

40

B52.01

32

IGLMVGGVV

300

24

VGSNKGAII

75

28

KGAIIGLMV

36

B62

32

IGLMVGGVV

5

B7

26

SNKGAIIGL

4

B8

26

SNKGAIIGL

4