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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury

Fig. 3

Representative immunoreactivity (IR) of the Schwann cell marker, S100, at the site of sciatic nerve injury in a sham, b Pain and disability, c Pain and transient disability and d Pain alone rats on day six after CCI. Scale bars represent 50 μm. Representative ATF3-IR, a marker of cellular stress, in the ipsilateral L4 DRG neurons in e sham, f Pain and disability, g Pain and transient disability and h Pain alone rats on day six after CCI. Arrowheads indicate ATF-IR nuclei. Scale bars represent 50 μm. i The ratio of S100-IR at the site of injury compared to an uninjured site following CCI (n = 11–14 per group). j The percentage of neurons with ATF3-IR nuclei compared to the total neurons counted in the ipsilateral L4 DRG after CCI (n = 4–7 per group). Significant differences compared to sham controls are indicated by *P <0.05 and ***P <0.001 for Pain and disability, ## P <0.01 and ### P <0.001 for Pain alone, and ^^^ P <0.001 for Pain and transient disability. All significant differences have been corrected for family-wise error rate with the Benjamini-Hochberg procedure, with a false discovery rate of q <0.05

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