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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury

Fig. 4

Representative ED1-IR, a macrophage marker, at the site of sciatic nerve injury in a sham, b Pain and disability, c Pain and transient disability and d Pain alone rats on day six after CCI. Scale bars represent 20 μm. e The percentage of ED1-IR (of total area) at the site of nerve injury after CCI (n = 9–13 per group). Scale bars represent 20 μm. f The number of ED1-IR cells per mm2 in the ipsilateral L4 DRG after CCI (n = 4–8 per group). Significant differences compared to sham controls are indicated by **P <0.01 for Pain and disability, # P <0.05 for Pain alone, and ^ P <0.05 and ^^ P <0.01 for Pain and transient disability. All significant differences have been corrected for family-wise error rate with the Benjamini-Hochberg procedure, with a false discovery rate of q <0.05

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