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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury

Fig. 5

Representative TCRαβ-IR, a T lymphocyte marker, at the site of sciatic nerve injury in a sham, b Pain and disability, c Pain and transient disability and d Pain alone rats on day six after CCI. Scale bars represent 20 μm. e The number of T lymphocytes per mm2 at the site of nerve injury after CCI (n = 9–14 per group). f The relationship between T lymphocytes in the sciatic nerve and the percentage change in dominance (from pre-CCI days 4–6 to post-CCI days 4–6) after CCI, in 33 rats. g The number of T lymphocytes per mm2 in the ipsilateral L4 DRG after CCI (n = 4–8 per group). h The relationship between the number of T lymphocytes in the ipsilateral L4 DRG and the percentage change in dominance (from pre-CCI days 4–6 to post-CCI days 4–6) after CCI, in 17 rats. Significant differences compared to sham controls are indicated by **P <0.01 and ***P <0.001 for Pain and disability, # P <0.05 for Pain alone and ^ P <0.05 for Pain and transient disability. Significant difference between Pain and disability and Pain alone is indicated by P <0.05. All significant differences have been corrected for family-wise error rate with the Benjamini-Hochberg procedure, with a false discovery rate of q <0.05

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