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Table 2 Mean cytokine concentration (pg/mL) (±SEM) in the ipsilateral L4-L5 DRG seven days following CCI

From: Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury

Cytokine Sham (n = 5) Combined CCI (n = 14) Pain and disability (n = 5) Pain and transient disability (n = 4) Pain alone (n = 5)
IL-1β 65.3 ± 10.4 98.9 ± 8.8 102.1 ± 16.6 111.1 ± 24.9 86.0 ± 6.1
IL-6 35.7 ± 6.8 82.5 ± 4.7*** 90.2 ± 9.9*** 78.9 ± 12.4 77.5 ± 2.2
IL-10 255.4 ± 44.3 251.1 ± 18.0 217.2 ± 21.0 310.6 ± 34.2 237.4 ± 31.6
IL-17A 98.6 ± 17.0 89.0 ± 6.6 77.3 ± 5.0 106.7 ± 18.1 86.5 ± 10.6
IL-18 117.6 ± 13.6 108.1 ± 4.9 98.7 ± 6.9 123.5 ± 9.7 105.1 ± 7.5
TNF 30.0 ± 3.2 28.7 ± 1.3 27.4 ± 2.2 30.9 ± 2.8 28.3 ± 2.4
IFN-γ 47.1 ± 10.8 46.7 ± 4.9 42.2 ± 6.0 56.7 ± 13.6 43.1 ± 5.1
MCP-1 83.1 ± 4.0 149.0 ± 7.6*** 152.1 ± 21.9** 136.8 ± 7.8 155.4 ± 3.8**
  1. Statistically significant differences compared to sham are indicated by *P <0.05, **P <0.01 and ***P <0.001. All significant differences have been corrected for family-wise error rate with the Benjamini-Hochberg procedure, with a false discovery rate of q <0.05