Skip to main content

Table 2 Mean cytokine concentration (pg/mL) (±SEM) in the ipsilateral L4-L5 DRG seven days following CCI

From: Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury

Cytokine

Sham (n = 5)

Combined CCI (n = 14)

Pain and disability (n = 5)

Pain and transient disability (n = 4)

Pain alone (n = 5)

IL-1β

65.3 ± 10.4

98.9 ± 8.8

102.1 ± 16.6

111.1 ± 24.9

86.0 ± 6.1

IL-6

35.7 ± 6.8

82.5 ± 4.7***

90.2 ± 9.9***

78.9 ± 12.4

77.5 ± 2.2

IL-10

255.4 ± 44.3

251.1 ± 18.0

217.2 ± 21.0

310.6 ± 34.2

237.4 ± 31.6

IL-17A

98.6 ± 17.0

89.0 ± 6.6

77.3 ± 5.0

106.7 ± 18.1

86.5 ± 10.6

IL-18

117.6 ± 13.6

108.1 ± 4.9

98.7 ± 6.9

123.5 ± 9.7

105.1 ± 7.5

TNF

30.0 ± 3.2

28.7 ± 1.3

27.4 ± 2.2

30.9 ± 2.8

28.3 ± 2.4

IFN-γ

47.1 ± 10.8

46.7 ± 4.9

42.2 ± 6.0

56.7 ± 13.6

43.1 ± 5.1

MCP-1

83.1 ± 4.0

149.0 ± 7.6***

152.1 ± 21.9**

136.8 ± 7.8

155.4 ± 3.8**

  1. Statistically significant differences compared to sham are indicated by *P <0.05, **P <0.01 and ***P <0.001. All significant differences have been corrected for family-wise error rate with the Benjamini-Hochberg procedure, with a false discovery rate of q <0.05