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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes

Fig. 4

Regulation of NF-κB and IRF3 activation in the spinal cord. a p65 and b IRF3 transcription factor activity as assessed by TransAM transcription factor ELISA. Nuclear extracts of the spinal cord of wild type, TNFR−/− and TBK1−/−/TNFR−/− mice were prepared from control mice and mice 2 h after injection of formalin into the hind paws (n = 3 mice/group); bright columns = control; dark columns = 2 h formalin, *P < 0.05, statistically significant differences compared with untreated control

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