Fig. 2

Lenalidomide reduces dopaminergic fiber loss in the striatum of mThy1-α-syn tg mice. a TH immunostaining of the striatum of non-tg and mThy1-α-syn tg mice treated with vehicle, lenalidomide, or thalidomide. b Optical density quantification of TH staining in the striatum. c α-syn immunostaining of the striatum of non-tg and mThy1-α-syn tg mice treated with vehicle, lenalidomide, or thalidomide. d Percentage of neuropil area positive for α-syn in the striatum. e α-syn immunostaining of the hippocampus of non-tg and mThy1-α-syn tg mice treated with vehicle, lenalidomide, or thalidomide. f Percentage of neuropil area positive for α-syn in the hippocampus. Error bars represent ± SEM. *, #p < 0.05; ##p < 0.01; ***p < 0.001. Scale bar = 50 μm