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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: The role of the prostaglandin E2 receptors in vulnerability of oligodendrocyte precursor cells to death

Fig. 7

The EP3 antagonist ONO-AE5-599 (AE) protects OPCs against excitotoxic death stimulated by BzATP (a specific agonist of P2X7). Dispersed OPCs were treated with BzATP (500 μM) in the presence or absence of AE5-599 (3 μM). Surviving cells were counted 48 h after treatment with BzATP. There was a greater than a twofold significant increase (P < 0.0001 by Student t-test) in surviving OPCs. This result is representative of five different experiments

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Journal of Neuroinflammation

ISSN: 1742-2094