Fig. 8From: The role of the prostaglandin E2 receptors in vulnerability of oligodendrocyte precursor cells to deathProtection of OPCs against TNFα-induced death. OPCs were treated with 400-ng recombinant mouse TNFα in the presence or absence of the EP3 antagonist ONO-AE5-599 (1 μM), and death was assessed 48 h later. There was a nearly twofold significant increase (P < 0.0001 by Student t-test) in surviving OPCs. This result is representative of five different experimentsBack to article page