Fig. 3
From: Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice
Apocynin treatment attenuates MOG-induced mononuclear cell infiltration into white matter of spinal cord and cerebellum in mice. Three weeks after the initial immunization of MOG, infiltration of mononuclear cells around small vessels in the spinal cord and cerebellum was detected with cresyl violet staining. EAE mice (EAE + vehicle, n = 3) revealed intensive infiltration of mononuclear cells around the white matter of the spinal cord (a) and cerebellum (c). However, apocynin treatment (EAE + apocynin, n = 3) reduced mononuclear cell infiltration into the white matter of the spinal cord. Scale bar represents 200 μm. The graphs represent number of infiltrated cells in the white matter of thoracic spinal cord (b) and cerebellum (d) with or without apocynin treatment in sham-operated and EAE mice. Data are mean ± sem (n = 3). *p < 0.05 compared with apocynin-treated group