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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain

Fig. 3

ELISA of (a) pro-inflammatory molecule IL-2 and (b) anti-inflammatory molecule IL-10 in the brain homogenates of rats exposed to hypoxia at 7620 m for 24 h. Hypoxic exposure resulted in to a significant increase in IL-2 followed by significant decrease in IL-10 levels in the brain of rats compared to control. However, curcumin treatment reversed the condition from pro-inflammatory to anti-inflammation by reducing IL-2 levels followed by enhanced IL-10 levels in the brain of rats under hypoxia compared to control (hypoxia) 24 h. Values are mean ± SD (n = 6). * p < 0.001 compared with normoxia (0 h) group. # p < 0.05 compared with hypoxia (24 h) group. Nor normoxia, Hypo hypoxia, Cur curcumin (100 mg/kg BW)

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