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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain

Fig. 5

Effect of curcumin (100 mg/kg BW) on the ion channel expression in the brain homogenate of rats exposed to hypobaric hypoxia at 7620 m for 24 h. a Represents Western blot analysis of ENaC protein, b Na+/K+-ATPase protein expression and c β-actin protein expression. Hypoxia downregulated the ENaC and Na+/K+-ATPase which were appreciably enhanced by curcumin administration 1 h prior to hypoxia exposure. a p < 0.001 compared with normoxia (0 h) group; b p < 0.001 compared with hypoxia (24 h) group; Nor normoxia, Hypo hypoxia, Cur curcumin (100 mg/kg BW)

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