Fig. 5

Effect of curcumin (100 mg/kg BW) on the ion channel expression in the brain homogenate of rats exposed to hypobaric hypoxia at 7620 m for 24 h. a Represents Western blot analysis of ENaC protein, b Na+/K+-ATPase protein expression and c β-actin protein expression. Hypoxia downregulated the ENaC and Na+/K+-ATPase which were appreciably enhanced by curcumin administration 1 h prior to hypoxia exposure. a p < 0.001 compared with normoxia (0 h) group; b p < 0.001 compared with hypoxia (24 h) group; Nor normoxia, Hypo hypoxia, Cur curcumin (100 mg/kg BW)