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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain

Fig. 6

Effect of curcumin (100 mg/kg BW) on the tight junction proteins expression in the brain homogenate of rats exposed to hypobaric hypoxia at 7620 m for 24 h. Western blot analysis of (a) ZO-1, b JAMC and (c) α-tubulin. Rats exposed to hypoxia showed downregulation of brain JAMC and ZO-1 protein expression levels compared to control. Curcumin restored the altered tight junction proteins integrity under hypoxia. a p < 0.001 compared with normoxia (0 h) group; b p < 0.001 compared with hypoxia (24 h) group. Nor normoxia, Hypo hypoxia, Cur curcumin (100 mg/kg BW)

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Journal of Neuroinflammation

ISSN: 1742-2094