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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury

Fig. 6

Schematic representation of astrocyte-macrophage interactions. M1 macrophages produce factors that induce astrocyte proliferation and reactive phenotype. These astrocytes are then able to increase TNFα expression on M1 macrophages. M2 macrophages produce factors that inhibit reactive astrocyte gene expression. Stimulated astrocytes can reduce the proliferation of both M1 and M2 macrophages and can dampen TNFα production in M1 macrophages

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