Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Fig. 1

Profile of the kynurenine pathway metabolites in the CSF of patients with TBI. The concentration of six tryptophan metabolites was measured in the CSF of TBI patients consecutively from the day of hospital admission (day 0) to day 5 after injury and compared to the CSF of control individuals. a Tryptophan (TRP), b kynurenine (KYN), c kynurenic acid (KYNA), d quinolinic acid (QUIN), e anthranilic acid (AA) and f 3-hydroxyanthranilic acid (3HAA). Data is presented as daily median with 25–75 percentile. Asterisks indicate significant differences (p < 0.05) to control using one-way ANOVA followed by Dunnett’s multiple comparison as post hoc. TBI patients: n = 25–28 per time point; control group: n = 9–11. Significant increase of KYNA concentration in CSF were observed between days 2 and 5 when compared to the control level, while QUIN concentration was significantly increased between days 1 and 5 as to the controls

Back to article page