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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Neuronal self-injury mediated by IL-1β and MMP-9 in a cerebral palsy model of severe neonatal encephalopathy induced by immune activation plus hypoxia-ischemia

Fig. 6

Effects of IL-1Ra on CINC-1 chemokine and PMN infiltration in LPS+HI-exposed brains. Decreased total cell percentage of PMN infiltration with IL-1Ra in the right frontoparietal neocortex at 48 h after LPS+HI (a). IL-1Ra prevented PMN (arrowhead) infiltration (IHC staining) in the infarcted neocortex of LPS+HI-exposed rats (b). Decreased relative expression of CINC-1 in the brain of LPS+HI+IL-1Ra-exposed rats compared to LPS+HI at 4 h (c). IL-1Ra decreased the titer (ELISA) of CINC-1 (pg/mg) within the right cerebral hemisphere at 4 and 24 h after LPS+HI (d). IHC of CINC-1 in the right frontoparietal neocortex 4 h after LPS+HI ± IL-1Ra (e). Error bars represent means ± SEM, scale bar = 10 μm, four to six animals per conditions, unpaired t test with Welch correction, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001. Abbreviations: PMN polymorphonuclear neutrophils, CINC-1 cytokine-induced neutrophil chemoattractant 1; WM white matter

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Journal of Neuroinflammation

ISSN: 1742-2094