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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Neuronal self-injury mediated by IL-1β and MMP-9 in a cerebral palsy model of severe neonatal encephalopathy induced by immune activation plus hypoxia-ischemia

Fig. 9

Effect of IL-1Ra on neuronal death effectors in LPS+HI-exposed brains. Decreased relative expression (IHC staining) of RIP-3 within right frontoparietal neocortex, but not in the WM and caudate putamen nuclei exposed to LPS+HI+IL-1Ra compared to LPS+HI at 4 h post-HI (a). Following LPS+HI insults, IL-1Ra decreased the percentage of caspase-3+ cells (IHC staining) in the striatum at 48 h post-HI (b). Error bars represent means ± SEM, four to six animals per conditions, unpaired t test with Welch correction, * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001. Abbreviations: RIP-3 receptor interacting protein 3, WM white matter

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