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Table 2 Multiple intraperitoneal challenges with lipopolysaccharide (LPS) in mice and rats

From: Systemic inflammation and microglial activation: systematic review of animal experiments

Study Genetic background N Age Sex Type of LPS Dose (mg/kg) Number of hits Total dose (mg/kg) Time of termination Microglial activation
Mice           
Frank-Cannon [38] C57BL/6 3 6–13 w U E. coli (O111:B4) 0.1 b.i.w. 16× 1.6 2 months No
       0.1 b.i.w. 24× 2.4 3 months Yes*
       0.1 b.i.w. 48× 4.8 6 months No
Katafuchi [68] C57BL/6 8 10 m M U 0.25 q.d. 1.75 7 days Yes
Lee [52] ICR 5 5 w M U 0.25 q.d. 1.75 18 days Yes
Nguyen [34] C57BL/6 U 6 m U E. coli (O55:B5) 1 q.2wk. 6 15 weeks No*
Franciosi [46] FVB/N 5 5 m B U 1 q.wk. 4 4 weeks Yes
    8 m     16× 16 17 weeks Yes
Chen [25] C57BL/6 4 8–12 w M E. coli (O55:B5) 1 q.d. 2 3 days Moderate*
        4 5 days Yes
Shankaran [69] C57BL/6 5 10–15 w F E. coli (O111:B4) 0.3 q.a.d. 1.2 7 days No
       1 q.a.d. 4 7 days Yes
       4 q.a.d. 16 7 days Yes
       4 q.a.d. 14× 56 4 weeks Yes
Rats           
Yin [70] Sprangue-Dawley 4 3 d M E. coli (O55:B5) 0.05 q.a.d 0.1 6 days Yes
          18 days Yes
          42 days No
Wu [9] Sprangue-Dawley 8 10 w M E. coli (U) 1.2 q.d. 14× 16.8 1 week Yes
  1. Column time of termination is the time from the (first) LPS challenge. All challenges were intraperitoneal
  2. Abbreviations: N number of animals per group, U unknown, M male, F female, B both sexes, m months, w weeks, d days, gr gram, q.d. every day, q.2wk once every 2 weeks, q.wk once a week, q.a.d. every other day, b.i.w. 2 times a week
  3. *Did not express data in statistical values, no statistical information