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Table 3 Challenge with pathogens in mice and rats

From: Systemic inflammation and microglial activation: systematic review of animal experiments

Study Genetic background N Age/weight Sex Pathogen Site of challenge Dose   
Mice          
Püntener [43] C57BL/6 3 >8 w F S. typhimurium (SL3261) ip 1 × 106 CFU 1 day No
         7 days Moderate
         21 days No
Rabchevsky [31] C57BL/6 6 6 w F CFA sc + ipl 150 ug 14 days No
         21 days No
Di Filippo [32] Biozzi ABH 4 6–8 w F CFA sc + ipl 100 ug U Yes
Rats          
Bland [71] Sprangue-Dawley 8 4 d M E. coli (ATCC 15746) sc 1 × 105 CFU/g 2 days Yes
         70 days Yes
         98 days Yes
Williamson [72] Sprangue-Dawley 9 4 d M E. coli (ATCC 15746) sc 1 × 105 CFU/g 2–3 months Yes
Bilbo [73] Sprangue-Dawley 6 4 d M E. coli (ATCC 15746) sc 1 × 105 CFU/gram 2 months No*
         16 months Yes
Bilbo [42] Sprangue-Dawley 8 4 d M E. coli (ATCC 15746) sc 1 × 105 CFU/g 56 days Yes
Bilbo [35] Sprangue-Dawley 6 4 d M E. coli (ATCC 15746) sc 1 × 105 CFU/g 56 days No
Bilbo [37] Sprangue-Dawley 8 4 d M E. coli (ATCC 15746) sc 1 × 106 CFU 2 h No
         8 h No
         1 day Yes
         2 days No
         3 days Yes
         2-3 months Yes
Raghavendra [4] Sprangue-Dawley 4 175–200 gr M CFA ipl 100 ul 4 h Moderate
         4 days Yes
         2 weeks Yes
Liu [30] Lewis 6 2 m F Heat-killed M. butyricum id 1.5 mg 3 weeks Moderate*
    12 m       Yes
Wu [29] Lewis 6 100–110 gr F Heat-killed M. butyricum id 25 mg/kg 2 weeks Yes
         3 weeks Yes
         4 weeks Yes
  1. Column time of termination is the time from the (first) LPS challenge
  2. Abbreviations: U unknown, F female, m months, d days, ip intraperitoneal, ipl intraplantar, M male, B both sexes, w weeks, gr gram, sc subcutaneous, id intradermal, N number of animals per group, CFA complete Freund’s adjuvant
  3. *Did not express data in statistical values, no statistical information