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Table 5 Intraperitoneal challenge with lipopolysaccharide (LPS) in knock-out mice

From: Systemic inflammation and microglial activation: systematic review of animal experiments

Study

Knock out gene

N

Age

Sex

Type of LPS

Dose

Time of termination

Microglial activation

Compared to wild-type

Bhaskar [23]

CX3CR1−/−

U

2 m

U

U

10 mg/kg

1 d

Yes*

More*

Terrando [22]

IL-1R−/−

4

12–14 w

M

E. coli (O111:B4)

1 mg/kg

1 d

No

Less*

       

3 d

No

Less*

       

1 w

No

Same*

Cardona [24]

CX3CR1−/−

U

U

U

U

20 ug q.d. 2×

4 d

Yes*

More*

Chen [25]

TLR4−/−

4

8–12 w

M

E. coli (O55:B5)

1 mg/kg q.d. 2×

4 d

No*

Less*

  1. Column time of termination is the time from the (first) LPS challenge. All challenges were intraperitoneal
  2. Abbreviations: U unkown, m months, d days, M male, w weeks, q.a.d every other day, N number of animals per group
  3. *Did not express data in statistical values, no statistical information