From: Systemic inflammation and microglial activation: systematic review of animal experiments
Study | Knock out gene | N | Age | Sex | Type of LPS | Dose | Time of termination | Microglial activation | Compared to wild-type |
---|---|---|---|---|---|---|---|---|---|
Bhaskar [23] | CX3CR1−/− | U | 2 m | U | U | 10 mg/kg | 1 d | Yes* | More* |
Terrando [22] | IL-1R−/− | 4 | 12–14 w | M | E. coli (O111:B4) | 1 mg/kg | 1 d | No | Less* |
 |  |  |  |  |  |  | 3 d | No | Less* |
 |  |  |  |  |  |  | 1 w | No | Same* |
Cardona [24] | CX3CR1−/− | U | U | U | U | 20 ug q.d. 2× | 4 d | Yes* | More* |
Chen [25] | TLR4−/− | 4 | 8–12 w | M | E. coli (O55:B5) | 1 mg/kg q.d. 2× | 4 d | No* | Less* |