Table 2 Study subjects for the assessment of IL-22 and IL-22 receptor in the brain
From: Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes
Patient | Gender | Age at surgery (years) | Type of surgery | Neuropathology reported from autopsy | Cause of surgery/death | Postmortem time (hours) | MS type | Disease duration (years) |
|---|---|---|---|---|---|---|---|---|
Lausanne cohort | ||||||||
L-C1 | F | 60 | Biopsy | – | Cerebellar softening | – | – | – |
L-C2 | M | 31 | Biopsy | – | Epilepsy | – | – | – |
L-C3 | F | 51 | Biopsy | – | Hematoma | – | – | – |
L-C4 | M | 43 | Biopsy | – | Aneurysm | – | – | – |
L-C5 | M | 41 | Biopsy | – | Hematoma | – | – | – |
L-C6 | n/a | n/a | Biopsy | – | Polymorphic neuroectodermal tumor | – | – | – |
L-C7 | n/a | n/a | Biopsy | – | Glioblastoma | – | – | – |
L-C8 | M | 32 | Biopsy | – | Cavernoma | – | – | – |
L-C9 | F | 53 | Biopsy | – | Epilepsy | – | – | – |
L-C10 | M | 51 | Biopsy | – | Malformation | – | – | – |
L-C11 | M | 39 | Biopsy | – | Epilepsy | – | – | – |
Basel cohort | ||||||||
B-C1 | M | 75 | Autopsy | Many documented neuropathological findings | Cerebrovascular accident, aspiration pneumonia | 17 | – | – |
B-C2 | M | 64 | Autopsy | Occasional hypoxic neurons, perineuronal oedema, stasis of erythrocytes in vessels, many leukocyte infiltrates | Cardiac failure | 18 | – | – |
B-C3 | M | 84 | Autopsy | Fibrosis of vessel walls, mild WM gliosis, perivascular oedema | Bladder cancer, pneumonia | 5 | – | – |
B-C4 | M | 35 | Autopsy | – | Carcinoma of the tongue | 22 | – | – |
B-C5 | M | 64 | Autopsy | Occasional hypoxic nerve cells, perineuronal oedema, fibrosis of the meninges | Cardiac failure | 18 | – | – |
B-C6 | F | 84 | Autopsy | Old cortical microinfarcts and acute global hypoxic changes. Senile changes are also present (amyloid deposits) | Congestive cardiac failure, ischemic heart disease, atrial fibrillation | 24 | – | – |
B-C7 | F | 60 | Autopsy | Brain with diffuse hypoxic changes | Ovarian cancer | 13 | – | – |
B-MS1 | M | 40 | Autopsy | No lesion, few leukocyte infiltrates | Respiratory failure, sepsis, MS | 10 | SP-MS | 9 |
B-MS2 | F | 78 | Autopsy | No lesion, some vessels with leukocyte infiltrates | Metastatic carcinoma of bronchus | 5 | SP-MS | 42 |
B-MS3 | F | 34 | Autopsy | Lesions in GM and WM, leukocytes around vessels | Pneumonia | 12 | SP-MS | n/a |
B-MS4 | F | 49 | Autopsy | Lesions in WM, leukocytes infiltrates | Bronchopneumonia, MS | 7 | SP-MS | 21 |
B-MS5 | M | 44 | Autopsy | n/a | Bronchopneumonia | 16 | SP-MS | n/a |