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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye

Fig. 4

ATAC treatment suppresses MAC deposition in the RPE/choroid. a, b At both ages of 7.5 months (a) and 11.5 months (b), western blot analysis showed that ATAC significantly reduced MAC deposits in rat RPE/choroid (Mann-Whitney, p ≤ 0.05). c At both ages, MAC immunoreactivity in the rat RPE/choroid was significantly lower in the ATAC-treated group compared to the age-matched, No ATAC control group (Mann-Whitney, p ≤ 0.05). d Representative micrographs from each group in c showed MAC immunoreactivity on the basal side of RPE cells and in choroid. Blue arrows identify positive MAC deposits labeled with VIP chromogen (purple). Nuclei were counterstained as green. Scale bar; 10 μm. RPE retinal pigment epithelium, Ch choroid

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Journal of Neuroinflammation

ISSN: 1742-2094