Fig. 1

rhPDCD5 treatment attenuates EAE development and protects spinal cord destruction. EAE mice treated with OVA or rhPDCD5 (10 mg/kg i.p.) a prophylactically every other day starting on day 0 following EAE induction and b therapeutically every other day from onset of EAE disease (day 8) were monitored daily for mean clinical score. Three independent experiments were performed. Data are means ± SEM from mice treated with OVA (n = 10) or rhPDCD5 (n = 10). Statistical analysis was performed using repeated measures two-way ANOVA followed by Bonferroni post hoc tests to compare replicate by time. *P < 0.05. c, d Representative microscopic photographs of spinal cord and semiquantitative histological evaluation for inflammation in EAE mice treated with OVA or rhPDCD5 (10 mg/kg, i.p.) prophylactically and therapeutically stained with H&E are shown. *P < 0.05, **P < 0.005