Fig. 5

rhPDCD5 induces apoptosis of MOG-stimulated T cells in vivo. a, c Lymphocytes were obtained from DLNs in EAE mice treated with OVA or rhPDCD5 prophylactically and therapeutically at day 25 after immunization, cultured with or without MOG_35–55 (20 μg/ml) for 48 h. Cellular apoptosis was analyzed by FITC-Annexin V plus anti-CD4-PE staining and flow cytometry. b, d Percentages of CD4⁺AV⁺ T cells are shown as means ± SEM (n = 10). **P < 0.005