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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease

Fig. 2

Expression of CXCR2 and IL-8 in ML region of rat dentate gyrus. a Representative RT-PCR for CXCR2 and IL-8 in controls (3 days post-injection of PBS or reverse peptide Aβ42–1) and in Aβ1–42-injected rat brain (1, 3, and 7 days post-injection); β-actin was used as a reaction standard. b Semi-quantification of RT-PCR for CXCR2 (left bar graph) and IL-8 (right bar graph); N = 5 animals per treatment group. c Typical CXCR2 ir for PBS, Aβ42–1, and Aβ1–42 (3 days post-injection); scale bar is for 70 μm. d Overall CXCR2 area density for the different animal groups (N = 4 animals per treatment group). Asterisk denotes p < 0.05 for Aβ1–42 vs PBS. e Representative Western blot for CXCR2 in control (3 days) and 1,3, and 7 days post-peptide injection. The bar graph shows relative CXCR2 levels for control and different durations of peptide injection (N = 4 animals per group)

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