Fig. 4
Effects of SB332235 on gliosis in ML region of dentate gyrus in peptide-injected hippocampus. a Representative microgliosis (Iba-1 marker) following 3 days injections with PBS (upper left panel), SB332235 alone (upper right panel), Aβ1–42 (lower left panel), and Aβ1–42 + SB332235 (lower right panel). b Overall area density for Iba-1 (N = 5 per treatment group). c Representative astrogliosis (GFAP marker) for PBS (upper left panel), SB332235 alone (upper right panel), Aβ1–42 (lower left panel), and Aβ1–42 + SB332235 (lower right panel). d Overall area density for GFAP (N = 5 per treatment group). Scale bars are for 80 μm. *p < 0.05 Aβ1–42 vs PBS; #p < 0.05 Aβ1–42 + SB332235 vs Aβ1–42