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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease

Fig. 5

Effects of SB332235 on area density for CXCR2 and microglia and astrocyte responses in proximity to peptide deposits in ML region. a Representative CXCR2 ir nearby Aβ1–42 (3 days post-Aβ1–42 injection) in the absence (left panel) and presence (right panel) of SB332235 treatment; scale bar is for 50 μm. b Overall CXCR2 area density (N = 5 per group) in a single quadrant within 300 μm of peptide. c Representative Iba-1 ir nearby Aβ1–42 in the absence (left panel) and presence (right panel) of SB332235 treatment; scale bar is for 30 μm. d Overall Iba-1 area density (N = 5 per group) in regions within 300 μm of peptide. e Representative GFAP ir nearby peptide deposits in the absence (left panel) and presence of SB332235 (right panel); scale bar is for 30 μm. f Overall GFAP area density (N = 5 per group) within 300 μm of peptide. *p < 0.05 for Aβ1–42 vs Aβ1–42 + SB332235

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