Fig. 5From: Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s diseaseEffects of SB332235 on area density for CXCR2 and microglia and astrocyte responses in proximity to peptide deposits in ML region. a Representative CXCR2 ir nearby Aβ1–42 (3 days post-Aβ1–42 injection) in the absence (left panel) and presence (right panel) of SB332235 treatment; scale bar is for 50 μm. b Overall CXCR2 area density (N = 5 per group) in a single quadrant within 300 μm of peptide. c Representative Iba-1 ir nearby Aβ1–42 in the absence (left panel) and presence (right panel) of SB332235 treatment; scale bar is for 30 μm. d Overall Iba-1 area density (N = 5 per group) in regions within 300 μm of peptide. e Representative GFAP ir nearby peptide deposits in the absence (left panel) and presence of SB332235 (right panel); scale bar is for 30 μm. f Overall GFAP area density (N = 5 per group) within 300 μm of peptide. *p < 0.05 for Aβ1–42 vs Aβ1–42 + SB332235Back to article page