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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Chronic morphine and HIV-1 Tat promote differential central nervous system trafficking of CD3+ and Ly6C+ immune cells in a murine Streptococcus pneumoniae infection model

Fig. 4

Enhanced chemokine expression of CXCR4 on immune cells isolated from the perfused brain of mice treated with morphine, HIV-1 Tat, and S. pneumoniae (S.p.) at the 5th day of post-pellet implantation. Flow cytometry profile of single-cell suspension. a Representative histograms demonstrate CXCR4 expression on leukocytes isolated from the CNS of treated mice. Histograms demonstrating CXCR4 expression (i and ii) on CD3+ and (iii and iv) on Ly6C+ cells. Bar diagrams representing quantification of CXCR4 expression on b CD3+ and c Ly6C+ cells as a mean fold change from placebo control [basal level (dashed line)]. Error bars indicate the standard error of the mean (SEM) of six different animals from each group (n = 6). PP placebo pellet, MP morphine pellet. *P < 0.05; **P < 0.01

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