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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Chronic morphine and HIV-1 Tat promote differential central nervous system trafficking of CD3+ and Ly6C+ immune cells in a murine Streptococcus pneumoniae infection model

Fig. 8

Differential trafficking of peripheral leukocytes with chemokine receptors (CCR5 and CXCR4) at day 5 into the CNS of wild-type (wt) and TLR knockout (TLRKO) mice treated with morphine and HIV-1 Tat and systemically infected with S. pneumoniae. Histogram of percentage mean leukocyte (CD3+ and Ly6C+) trafficking with CCR5 and CXCR4 into the CNS of wt and TLRKO mice. Error bars indicate the standard error of the mean (SEM) of six different animals from each group (n = 6). PP placebo pellet, MP morphine pellet. *P < 0.05; **P < 0.01

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