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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: HLA-DRα1-mMOG-35-55 treatment of experimental autoimmune encephalomyelitis reduces CNS inflammation, enhances M2 macrophage frequency, and promotes neuroprotection

Fig. 6

DRα1-mMOG-35-55 treatment reduces the expression of pro-inflammatory genes and increases the expression of genes involved in neurosurvival and regeneration. a Gene expression profile of spinal cords of DR*1501-Tg mice with EAE that were treated with DRα1-mMOG-35-55 (n = 3) or vehicle (n = 3). mRNA was pooled for microarray analysis. Gray circles represent probes that were at least twofold down- or upregulated after DRα1-mMOG-35-55 treatment relative to vehicle treatment. b Relative expression of mRNA of CD74, NLRP3, IL-1b, HUWE1, MBP, and HDAC5 was analyzed by real-time PCR from spinal cord samples of DRα1-MOG-35-55-treated (n = 3) relative to vehicle-treated (n = 3) mice. *p < 0.05, **p < 0.01, p < 0.001, Student’s t test

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Journal of Neuroinflammation

ISSN: 1742-2094