Fig. 9
From: Cu(II) enhances the effect of Alzheimer’s amyloid-β peptide on microglial activation
Effects of NAC on Cu(II)-Aβ complex-induced microglial activation and the indirect neurotoxicity. TNF-α (a) and nitric oxide (b) concentration in the media from BV-2 cells treated with Cu(II)-Aβ1–40 (5 μΜ peptide) for 24 h with or without NAC (1 mM). c Cell viability of hippocampal neurons treated with conditioned media (CM, at 50 % of neuronal culture media) from primary microglia stimulated with Cu(II)-Aβ1–40 in the presence or absence of NAC. Data are expressed as the means ± SEM of at least three independent experiments. Significance was tested by one-way ANOVA followed by Bonferroni post-test comparisons. *P < 0.05, **P < 0.01 vs control (a, b) or con-CM (c); # P < 0.05 vs Cu-Aβ (a, b) or Cu-Aβ-CM (c)