Fig. 3

TNF^−/− mice are highly susceptible to CNS-TB but NsTNF^−/− mice are resistant. TNF^f/f (black circle), NsTNF^−/− (triangle), and TNF^−/− (clear circle) mice were infected with M. tuberculosis H37Rv at a dose of 1 × 10³–1 × 10⁴ CFUs/brain by intracerebral inoculation. Body weight changes (a) and mortality (b) were measured and recorded for the experimental duration (n = 10–12 mice/group). c Brain weights of infected mice were recorded at 1, 2 and 3 weeks post-infection (n = 5–6 mice/group). d The clinical scores, indicative of the disease severity, are represented (n = 10–12 mice/group). The data represents three to five similar experiments. *p ≤ 0.05