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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis

Fig. 4

TNF is required to control intracerebral M. tuberculosis replication but neuron-derived TNF is redundant. TNFf/f (black circle), NsTNF−/− (triangle) and TNF−/− (clear circle) mice (n = 5–6/group) were infected with M. tuberculosis at a dose of 1 × 103–1 × 104 CFUs/brain. Bacterial burdens in a, b brains; c, d spleens; and e, f lungs at 1, 2, 3 (left panel; a, c, e, respectively) and 15 weeks (right panel; b, d, e respectively) post-infection were determined. Data (mean ± SEM of the CFUs of 5–6 mice per time point) are representative of three similar experiments. *p ≤ 0.05; **p ≤ 0.01

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