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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Tumor necrosis factor-α enhances voltage-gated Na+ currents in primary culture of mouse cortical neurons

Fig. 2

Time-dependent effects of TNF-α on Na+ currents and electrophysiological characteristics of Na+ currents. a Current density–voltage relationship in the group treated with 100 and 1000 pg/ml TNF-α and control group for 24 h. b Time dependency of TNF-α (100 and 1000 pg/ml) effects on Na+ currents ranging from 0 to 48 h. Current data were normalized by the control and expressed as percentage of the control group. *P < 0.05 as compared with 0 h group, # P < 0.05 the 100 or 1000 pg/ml TNF-α-treated group (24 h) vs. the control group (24 h), and 1000 pg/ml TNF-α-treated group (24 h) vs. the control group (48 h) (two-way ANOVA). c Voltage-dependent activation curves (Boltzmann equation and fitting parameters) in the 100 pg/ml TNF-α-treated (24 h) and 24 h control groups. d Voltage-dependent fast-inactivation curves (Boltzmann equation and fitting parameters) in the 100 pg/ml TNF-α-treated (24 h) and 24 h control groups

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