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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Tumor necrosis factor-α enhances voltage-gated Na+ currents in primary culture of mouse cortical neurons

Fig. 4

Inhibition of NF-κB and p38 MAPK decreased the TNF-α augmentation of Na+ currents. a Typical recording curves of whole-cell Na+ currents from −80 to 100 mV in the control and TNF-α (100 ng/ml, 24 h), TNF-α + BAY 11-7082(1 uM), and TNF-α + SB203580 (1 uM)groups. b Normalized peak current–voltage relationship in the control and TNF-α (100 pg/ml, 24 h), TNF-α + BAY 11-7082(1 uM), and TNF-α + SB203580 (1 uM) groups. *P < 0.05 vs. the 24 h control group; # P < 0.05 vs. TNF-α (100 pg/ml, 24 h) group (one-way ANOVA followed by SNK). c Voltage-dependent activation curves (Boltzmann equation and fitting parameters) in the TNF-α (100 pg/ml, 24 h), TNF-α + BAY 11-7082, and TNF-α + SB203580 groups. d Voltage-dependent inactivation curves (Boltzmann equation and fitting parameters) in the TNF-α (100 pg/ml, 24 h), TNF-α + BAY 11-7082, and TNF-α + SB203580 groups

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