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Table 1 The effect of TNF-α (100 pg/ml 24 h) on Na+ channel kinetics

From: Tumor necrosis factor-α enhances voltage-gated Na+ currents in primary culture of mouse cortical neurons

 

Activation

Inactivation

 

Control (n = 10)

TNF-α (n = 17)

Control (n = 15)

TNF-α (n = 19)

V 1/2 (mV)

−37.01 ± 0.46

36.07 ± 0.48

−53.07 ± 0.43

56.95 ± 0.39*

Slope factor

2.907 ± 0.39

2.929 ± 0.42

6.528 ± 0.38

6.117 ± 0.33

  1. V 1/2 voltage of half-maximal activation or inactivation, k slope, TNF-α (100 pg/ml, 24 h)
  2. * P < 0.001 vs. the control
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Journal of Neuroinflammation

ISSN: 1742-2094