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Table 2 Effects of SB203580 and BAY11-7082 on Na+ channel kinetics in neurons treated by TNF-α

From: Tumor necrosis factor-α enhances voltage-gated Na+ currents in primary culture of mouse cortical neurons

 

Activation

Inactivation

 

TNF-α (n = 7)

TNF-α + SB203580 (n = 12)

TNF-α + BAY11-7082 (n = 15)

TNF-α (n = 9)

TNF-α + SB203580 (n = 9)

TNF-α + BAY11-7082 (n = 8)

V 1/2 (mV)

−31.47 ± 0.38

−29.32 ± 0.36

−29.9 ± 0.62

−55.33 ± 0.31

−54.21 ± 0.61

53.04 ± 0.34*

Slope factor

3.553 ± 0.31

3.681 ± 0.31

4.867 ± 0.54

5.003 ± 0.27

6.380 ± 0.54

5.453 ± 0.30

  1. V 1/2 voltage of half-maximal activation or inactivation, k slope, TNF-α (100 pg/ml, 24 h)
  2. * P < 0.001 vs. TNF-α (100 pg/ml, 24 h) group (one-way ANOVA followed by SNK)
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Journal of Neuroinflammation

ISSN: 1742-2094