Fig. 2
From: STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE
Th1 and Th17 CD4 T cell production of GM-CSF is dependent on STAT4 during EAE. MOG35–55 specific cytokine production was assessed in the dLN from WT and STAT4−/− mice 10 days after EAE induction. a Representative plots are gated on CD44hiCD4+ T cells, and either GM-CSF+ (top) or GM-CSF− (bottom) CD4+ T cells. The (b) frequencies and (c) numbers of single, double, and triple cytokine-producing CD44hiCD4+ T cells are shown. Data represent three independent experiments with 3–5 mice in each group. Student’s t test was performed: ns = not significant; *p < 0.05; **p < 0.01; ***p < 0.001