Pathogenesis of intracranial aneurysm is mediated by proinflammatory cytokine TNFA and IFNG and through stochastic regulation of IL10 and TGFB1 by comorbid factors

Table 2 Comparison of the genotype and allele frequencies of associated cytokine gene variants between patients and controls

					p value			OR(95 %CI)	p value	FS score
IFNG		AA	AG	GG		A	G
rs2069718	Cases	79	103	39	0.020	261	181	1.20 (0.926 to 1.560)	0.184	ND
	Cases	0.36	0.47	0.18		0.59	0.41
	Controls	61	143	39		265	221
	Controls	0.25	0.59	0.16		0.55	0.45
TNF		GG	AG	AA		G	A
rs361525	Cases	171	42	2		384	46	1.89 (1.163 to 3.064)	0.010	0.208
	Cases	0.80	0.20	0.01	0.019	0.89	0.11
	Controls	216	25	2		457	29
	Controls	0.89	0.10	0.01		0.94	0.06
IL6		GG	GC	CC		G	C
rs1800796	Cases	57	126	37	0.050	240	200	0.94 (0.729 to 1.225)	0.691	0.208
	Cases	0.26	0.57	0.17		0.55	0.45
	Controls	81	111	52		273	215
	Controls	0.33	0.45	0.21		0.56	0.44
IL10		CC	CT	TT		C	T
rs1800871	Cases	48	142	40	0.016	238	222	1.08 (0.837 to 1.396)	0.558	0.101
	Cases	0.21	0.62	0.17		0.52	0.48
	Controls	61	118	62		240	242
	Controls	0.25	0.49	0.26		0.50	0.50
IL10		AA	AC	CC		A	C
rs1800872	Cases	39	143	48	0.005	221	239	0.955 (0.740 to 1.233)	0.745	0.101
	Cases	0.17	0.62	0.21		0.48	0.52
	Controls	62	116	66		240	248
	Controls	0.25	0.48	0.27		0.49	0.51

ISSN: 1742-2094