Target structures | Comments | Ref |
---|---|---|
Purkinje cells | ||
MGluR1/calcium pathway-related | ||
Anti-mGluR1 | Tumour-associated in some cases | |
Anti-Homer-3 | Lung cancer-associated in one unpublished cases | |
Anti-Sj/ITPR1 | NSCLC-associated in one unpublished case | [100] |
Anti-CARP VIII | Reported in association with melanoma and ovarian cancer | |
Anti-PKCγ | Reported in association with SCLC and liver cancer | |
Anti-GluRδ2 | Mostly para/postinfectious | |
Anti-Ca/ARHGAP26 | Tumour-associated in a few cases | |
Anti-P/Q-type VGCC | Tumour-associated in many cases | |
Anti-N type VGCC | Often associated with anti-P/Q-type VGCC | |
Anti-Yo/CDR2 (PCA-1)a | Typical paraneoplastic syndrome | |
Anti-Nb/AP3B2/beta-NAP | Tumour-association unknown | |
Others | ||
PCA-2 (target antigen not known) | Tumour-associated in almost all published cases | [154] |
Anti-Tr/DNER | HD-associated in almost all cases | |
Molecular and granular layer, PCs spared | ||
Anti-amphiphysin | Tumour-associated in most cases | [170] |
Anti-GABABR | Tumour-associated in many cases | |
Anti-DPPX | Reported in association with B cell neoplasm in a few patients | |
Anti-Caspr2 | Facultatively paraneoplastic | |
Pinceau formation/Basket cells | ||
Anti-LGI1 | Mainly not tumour-associated | [177] |
Granular layer | ||
Anti-GAD | DM-associated (mostly DM type I) and, in neurological patients, often tumour-associated | |
Oligodendrocytes | ||
Anti-CV2/CRMP5 | Typical paraneoplastic syndrome | |
Anti-MOG | Usually non-paraneoplastic | |
Astrocytic endfeet | ||
Anti-AQP4 | Very rarely causing cerebellar ataxia, usually non-paraneoplastic | |
Neuronal nuclei | ||
ANNA-1 (Anti-Hu/HuD) | Neuronal nuclei in the CNS and PNS paraneoplastic | |
ANNA-2 (Anti-Ri) | Neuronal nuclei in the CNS paraneoplastic | |
ANNA-3 (unknown antigen) | Typical paraneoplastic syndrome | [194] |
Anti-Zic4 | Typical paraneoplastic syndrome | |
Anti-Zic2 | Mostly SCLC-associated | [197] |
Anti-Zic1 | Mostly SCLC-associated | [197] |
Bergman glial cell nuclei | ||
AGNA/Anti-SOX1b | Typically tumour-associated | |
Nucleoli | ||
Anti-Ma2/Ta (PNMA2) | Typical paraneoplastic syndrome | |
Anti-Ma1 (PNMA1) | Typical paraneoplastic syndrome | |
Centrosome | ||
Anti-γγ-enolase, -pericentrin, -ninein, -PCM1, -Mob1 | Para-/post varicella zoster virus | [202] |
Centriols | ||
Anti-centriolar antibodies | Para-/post M. pneumoniae | [203] |
Others | ||
Anti-transglutaminase6 | Associated with celiac disease | |
Anti-triophosphate isomerase | Post-EBV | [206] |
Anti-20 S proteasome | Associated with anti-Yo | [207] |
Anti-GQ1b | ‘Ataxic Guillaine Barré syndrome’ |