Fig. 5

A high-fat diet alters the peripheral inflammatory response after stroke. Male C57BL/6 mice (8-week-old) were maintained on either a control or high-fat diet for 6 months and MCAo performed for either 20 or 30 min. CXCL-1 expression was analysed in the plasma (a, b) at 0, 4 and 24 h after reperfusion. In the liver (c, d) CXCL-1 expression was analysed at 24 h after MCAo and data compared to naïve mice. For this group of animals, the data for volume of ischaemic damage at 24 h is illustrated in Fig. 1d, e. n.d., not detected. Data are shown as mean ± standard error of the mean (SEM). n = 4–7/group. *P < 0.05, **P < 0.01, ***P < 0.001. Two-way ANOVA with Bonferroni’s