Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke

Table 1 Physiological response to a high-fat diet in mice

	2 month		3 month		4 month		6 month
	Control	High-fat	Control	High-fat	Control	High-fat	Control	High-fat
Body weight gain (g)	5.2 ± 0.6	16.3 ± 1.3***	6.0 ± 2.0	23.0 ± 0.7***	7.6 ± 0.6	25.8 ± 0.9***	9.6 ± 1.4	28.4 ± 1.8***
Glucose (mmol/l)	7.1 ± 0.3	8.9 ± 0.4**	9.4 ± 0.5	11.0 ± 0.5*	8.4 ± 0.4	10.1 ± 0.5*	8.9 ± 0.7	10.7 ± 0.5*
Systolic blood pressure (mmHg)	-	-	105.8 ± 2.7	106.0 ± 1.7	-	-	106.1 ± 2.9	114.6 ± 6.7
Diastolic blood pressure (mmHg)	-	-	47.6 ± 1.6	51.2 ± 4.9	-	-	49.9 ± 4.0	52.7 ± 3.4

Separate groups of mice were maintained on a high-fat or control diet for 2, 3, 4 or 6 months when body weight gain (g, from week 0 on diet), blood glucose (mmol/l) and systolic and diastolic blood pressure (mmHg, in 3 and 6 month groups only) were assessed
Data are mean ± standard error of the mean (SEM), n = 5–12/group
*P < 0.05, **P < 0.01, ***P < 0.001 versus control-fed mice. Student’s t-test

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