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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

Fig. 1

HMGB1 was actively involved in the pathogenesis of retinal IR injury. a Hematoxylin and eosin staining of retina showed the degeneration of RGCs and mean thickness decrease of ischemic retinal tissue at different time points after reperfusion. GCL ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, ONL outer nuclear layer, OPL, outer plexiform layer. b Western blot analysis of the cytoplasmic protein levels of HMGB1 at different time points after reperfusion. Each protein expression level is shown relative to that of controls. c The function of HMGB1 on the retinal tissue damage in retinal IR injury. The sham procedure was performed without elevating the container in contralateral eyes as control groups and retinal ischemia reperfusion (IR) injury was observed at 48 h after reperfusion. # P < 0.05 (IR vs IR + rH, IR vs IR + GA). d RGCs marker β3-tubulin detected RGCs damage by immunofluorescent staining in experimental groups. Data are shown as mean ± SD or percentage. *P < 0.05, **P < 0.01 vs sham group

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