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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

Fig. 2

HMGB1 promoted non-canonical caspase-8 inflammasome assembled in retinal IR injury. a, b RT-PCR analyzed caspase-8 mRNA expression. c, d Western blot detected expression of cleaved caspase-8 protein. e rHMGB1 could stimulate the activation of caspase-8 in RGCs, while inhibition of HMGB1 significantly suppressed the activation by confocal microscope. f, g ASC immunoprecipitated with caspase-8 and assembled caspase-8-ASC complex in IR model. h, i HMGB1 promoted caspase-8-ASC protein complex formation. Data are shown as mean ± SD. *P < 0.05, **P < 0.01 vs sham group

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Journal of Neuroinflammation

ISSN: 1742-2094