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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Chronic inflammatory demyelinating polyneuropathy (CIDP): change of serum IgG dimer levels during treatment with intravenous immunoglobulins

Fig. 1

a Chromatography elution profile of representative pre-IVIg (black) and post-IVIg (grey) treatment sera. Dimeric IgG fractions (arrow) can be detected in post-IVIg treatment samples. b Gel electrophoresis of purified IgG fractions. Heavy chain (56 kDa) and light chain (25 kDa) of CIDP patient monomeric IgG fraction pre-IVIg (1) and post-IVIg (2) treatment could be detected. IgG purity in CIDP patient dimeric IgG fraction post-IVIg is also shown (3) compared to IgG of healthy control (4) and commercial IVIg preparation (5). c Dimer content of CIDP patients (n = 16) pre- and post-IVIg treatment. Dimer content is significantly increased after IVIg treatment. Change of dimeric IgG fraction in CIDP patients (n = 16) pre- and post-IVIg treatment. d CIDP patients with stable/improving course of disease show significantly higher dimeric IgG compared to worsening patients. e, f CIDP patients with stable/improving clinical course of disease after receiving either IVIg preparation #1 (e) or #2 (f) show a significant increase of dimeric IgG fraction post-treatment (*p < 0.05; **p < 0.01; ***p < 0.001); ****p < 0.0001)

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Journal of Neuroinflammation

ISSN: 1742-2094