Fig. 6

Proportion of BDNF positive microglial cells. Average percentage of Iba-1 positive cells that co-label with BDNF in the dentate gyrus of adult and aged mice (a). An age x exercise interaction showed that wheel running increased the proportion of BDNF and Iba-1 co-labeled cells only in the aged mice. Representative image of cells co-labeled with antibodies against Iba-1 (macrophage/microglia; blue) and BDNF (neurotrophic factor; red) from an aged control (b) and aged exercise (c) mouse. Arrows point to co-labeled cells. Bars with different letters are significantly different from each other. Means ± SEM